Henry Isham had a daughter who married the first of the Randolphs to emigrate to Virginia belonged to a family which had been long seated in Northampshire, represented in the English baronetage. He was a nephew to Sir Edward Brett, knighted by Charles I for brilliant services as an officer and who by his last will and testament devised a considerable estate to Isham's two daughters. Isham resided in Virginia for a time, but ultimately returned to England where he died. Source: Waters' Gleanings, pp. 447-8.